The role of glucocorticoid and mineralocorticoid receptor DNA methylation in antenatal depression and infant stress regulation

M Galbally; SJ Watson; M van IJzendoorn; R Saffery; J Ryan; ER de Kloet; TF Oberlander; M Lappas; AJ Lewis

Journal article

The role of glucocorticoid and mineralocorticoid receptor DNA methylation in antenatal depression and infant stress regulation

M Galbally, SJ Watson, M van IJzendoorn, R Saffery, J Ryan, ER de Kloet, TF Oberlander, M Lappas, AJ Lewis

Psychoneuroendocrinology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020

DOI: 10.1016/j.psyneuen.2020.104611

Abstract

Understanding fetal programming pathways that underpin the relationship between maternal and offspring mental health necessitates an exploration of potential role of epigenetic variation in early development. Two genes involved in stress response regulation, the glucocorticoid and mineralocorticoid receptors (NR3C1 and NR3C2) have been a focus in understanding stressful exposures and mental health outcomes. Data were obtained from 236 pregnant women from the Mercy Pregnancy Emotional Wellbeing Study (MPEWS), a selected pregnancy cohort, recruited in early pregnancy. Depression was measured using the Structured Clinical Interview for DSM-IV (SCID-IV) and repeated measures of the Edinburgh Pos..

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University of Melbourne Researchers

Megan Galbally Author

Richard Saffery Author

Martha Lappas Author

Related Projects (1)

THE TRANSMISSION OF PERINATAL MATERNAL MENTAL HEALTH TO PRESCHOOL EMOTIONAL DISORDERS: EXAMINING PATHWAYS AND INTERVENTION POINTS IN THE MPEWS STUDY

While it is known that depression, anxiety and stress in pregnancy increase the risk for poorer child mental health, what is unknown is the ..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study is supported through the 2012 National Priority Funding Round of Beyond blue in a three-year research grant (ID 519240) and a 2015 National Health and Medical Research Council (NHMRC) project grant for 5 years (APP1106823). Financial support has also been obtained from the Academic Research Development Grants from Mercy Health and from the Centre for Mental Health and Well-Being, Deakin University.